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Use of weight-bearing MRI for evaluating wheelchair cushions based on internal soft-tissue deformations under ischial tuberosities

Nogah Shabshin, MD;1,/ Gil Zoizner, BSc;2 Amir Herman, MD;34 Vlad Ougortsin, MD;3 Amit Gefen, PhD5*
1Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Orthopaedic Surgery, Sheba Medical Center, Tel Aviv, Israel; 4Department of Statistics, University of Haifa, Mount Carmel, Haifa, Israel; 5Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel

AbstractDeep tissue injury (DTI) is a severe type of pressure ulcer, in which damage initiates under intact skin, in soft tissues that are mechanically deformed by load-bearing bony prominences. Sitting-acquired DTI typically occurs in the gluteus muscles that could sustain deformations by the weight-bearing ischial tuberosities (ITs). No clinical method currently exists for measuring internal tissue deformations; so design and selection of wheelchair cushions are based mostly on meas-uring sitting pressures. Our objective was to evaluate the influence of different commercial cushions on internal soft-tissue deformations under the ITs, using weight-bearing magnetic resonance imaging (MRI). We specifically compared muscle, superficial fat, and effective (muscle and fat together) tissue deformations while subjects (n = 10) sat on four cushions (two viscoelastic and two foam) and directly on a rigid support. Deformations were maximal in muscle tissue (mean ~70%), twice more the amount than in fat (~30%). Effective soft-tissue deformations were ~50% to ~60%. Although cushions mildly reduced muscle deformations in the order of 10%, theoretically, our interpretation suggests that this deformation level adds safe sitting time. This study demonstrated that weight-bearing MRI is applicable for evaluating wheelchair cushions and, in the future, may be a tool to systematically support cushion design and selection.


Pressure ulcers are a major cause of morbidity and mortality, particularly in individuals who use a wheelchair because of neuromuscular disorders. The lifetime risk for developing a pressure ulcer in this population was estimated to be 25 to 85 percent [1]. Furthermore, the cost of treatment of pressure ulcers exceeds $1 billion annually in the United States alone [2]. Thus, prevention of this pathology is crucial.

this pathology is crucial. Recently, research has shown that many of the pressure ulcers previously classified as stage 3 or stage 4 (severe) are actually a distinct category, now defined by the National Pressure Ulcer Advisory Panel (Washington, DC) ( as a deep tissue injury (DTI) [34]. The pathophysiological mechanism of DTI is completely distinct from that of superficial pressure ulcers. The injury initiates in deep soft tissues, probably in skeletal muscle tissue that is mechanically deformed directly by weight-bearing bony prominences [5]. Most of the sitting-acquired DTI cases occur in the gluteus muscles that are subject to sustained deformations by the weight-bearingischial tuberosities (ITs) during sitting [5]. Necrosis of the deep and superficial soft tissues around the IT may be present in such DTI cases under intact skin and before skin changes occur [3,67].

Numerous types of wheelchair cushions are available commercially, and nearly all claim to prevent, or at least delay, pressure ulcer development of all kinds, including DTI. Selecting a cushion for an individual is a complex process that involves comfort, postural, functional, and safety considerations, which do not always coincide [8]. The number of randomized controlled trials (RCTs) that tested the efficacy of prevention with a clinical outcome islow, and so such studies do not show a consensus regardingsuperior performances of a certain cushion [9]. These RCTstudies are also difficult to conduct, mostly because

  1. High sample sizes are required (e.g., because of difficulties in recruiting suitable subjects, high drop-out rates, and sometimes low incidence rates of pressure ulcers or DTI during the study period).
  2. Pressure ulcers and DTIs should be definitively and timely identified, but this is not straightforward, e.g., because of the nature of DTIs that is concealed at early stages.
  3. Problems exist in isolating the effect of the cushion from other interfering clinical variables (e.g., comorbidities that are common in populations susceptible to pressure ulcers), environmental factors, and performanceof the caregivers [911].

Various objective parameters, including contact pressures during sitting, buttocks skin temperatures, and humidity, have been used to evaluate the efficacy of cushions in preventing pressure ulcers [12], with contact pressure measurements being the most popular tool. However, no agreed threshold for the allowed sitting pressure exists in the literature, as explained in recent articles stating that internal anatomy and mechanical properties of tissues can cause substantial differences in internal tissue loading between individuals, even when their sitting pressures are similar [1315].

Increasing evidence shows that DTI develops in deep tissues because of sustained mechanical deformations that damage cells directly as well as obstruct blood flow [1618]; however, no quantitative noninvasive clinical method exists for measuring internal mechanical conditions in deep tissues. In a previous basic science study, we used magnetic resonance imaging (MRI) to demonstrate internal soft-tissue deformations in the buttocks during weight-bearing sitting [1415]. In the current study, we sought to use a similar method to evaluate the influence of different types of commercial wheelchair cushions on internal tissue deformations in the buttocks, under the IT. Specifically, we compared muscle, superficial fat, and overall soft-tissue deformations under the IT while subjects sat on different types of commercial cushions (viscoelastic, foam) and directly on a rigid support, within an open-magnetic resonance (MR) system.


Ten nondisabled volunteers were recruited: seven malesand three females. Subjects were aged 33 5 years (valuesare shown as mean standard deviation throughout the article unless otherwise stated). Their height and weight were 177 5 cm and 73.5 10.9 kg, respectively, giving a body mass index of 23.5 3.2 kg/m2. All subjects had average body habitus. Exclusion criteria included absolute and relative contraindication for MRI, e.g., cardiac pacemakers (or other metallic implants) or metallic foreign bodies, as well as pregnancy, claustrophobia, psychiatric disorders, and limitations on sitting still for prolonged time periods. We further excluded subjects with known underlying diseases that impair mobility and those with a history of pelvic fractures or pelvic surgery.

MRI Scan Protocol
Subjects were scanned on a 0.5 T open MR system (Signa SP, GE Medical Systems; Milwaukee, Wisconsin).This system has a double-donut configuration that allows subjects to sit in the magnet, between the two donuts. Images of the buttocks were obtained with coronal T1-weighted images* (time of repetition/time of echo =440/28, field of view = 240 mm, slice thickness = 4 mm). We used T1-weighted images because they provide the best anatomic contrast: fat shows high-intensity signal, whereas skeletal muscle and fluid show low signal. All scan images, which are common sites for sitting-acquired pressure ulcers and DTI, were focused on the IT [5].

*T1 is a time constant that indicates mode of MRI scans. T1-weighted imaging is one of the basic types of MRI contrast commonly used in clinical scans for demonstrating soft-tissue structures.

Subjects were first scanned in a neutral non-weight-bearing sitting posture and then again while sitting on four different cushions as described in the next section. For the non-weight-bearing scan, subjects were asked to sit neutrally (upright, relaxed) on an air-inflated rubber tire placed on the MRI table so that the buttocks region under the IT was unloaded. A flexible MRI coil was placed under the tire. Next, the tire was removed and subjects were scanned again in a weight-bearing posture, while sitting on a custom-made, MR-compatible chair designed for this purpose (Figure 1), simulating a wheelchair (wheelchairs contain metallic components and therefore could not be used for the MRI studies). The chair was made of plastic, with an erect backrest and a buttocks support area that was 61 cm wide (which fitted exactly in the MRI space between the magnet parts). We further used armrests and footrests to simulate a wheelchair sitting posture (Figure 1(a)), but the (nondisabled) subjects were instructed to use the armrests/footrests for comfortable sitting, rather than for supporting their body weight. The chair was mounted on the MR table and was used in the weight-bearing sitting MR scans (Figure 1(b)).Each subject underwent five weight-bearing scans: sitting directly on the chair (rigid support) and then on each of four cushions (details in the following section). While cushions were replaced, subjects were asked to lift their buttocks as minimally as possible to avoid major postural changes. Markers on the chair were used to maintain comparable buttocks positions for each cushion placed on the chair by aligning the midline of the body with a frontal marker on the chair and the greater trochanter with a lateral marker on the chair.

table 1

Four cushions were selected for the study: two standard commercial viscoelastic cushions (A and B) and two standard commercial foam cushions (C and D), with thicknesses and mechanical properties as specified in Table 1. The elastic modulus of each cushion was meas-ured before the MRI trials in a laboratory setting. Specifically, we tested viscoelastic cushion A in an indentationtest configuration using a half-spherical indenter attached to an electromechanical uniaxial testing machine (Instron 5544; High Wycombe, United Kingdom), which deformedthe cushion at a rate of 20 mm/min. We calculated the long-term elastic moduli of cushion A using the Hertz solution for this indenter-cushion contact problem, as described by Agam and Gefen for indentation strains of 60, 70, and 80 percent [19] (typical cushion strains under a body weight [20]), after allowing 1 minute of stress relaxation. Cushions B, C, and D were tested in a compression configuration. Material specimens of 6.5 6.5 6.5 cm were cut from each cushion. The specimen from cushion B, which is also marketed as a viscoelastic cushion (Table 1), was tested for long-term elastic moduli at 60, 70, and 80 percent strain, similarly to the test protocol for cushion A. The specimens from the foam cushions C and D were compressed up to 80 percent strain, again at a rate of 20 mm/min, and their tangent (instantaneous) elastic moduli recorded. Tangent moduli were recorded for cushions C and D since, unlike the viscoelastic cushionsA and B, cushions C and D did not show substantial viscoelastic behavior (i.e., stress relaxation) at large cushion strains (Table 1).

fig 1a

fig 1b
Figure 1.Experimental design of magnetic resonance imaging (MRI) studies: (a) scheme and (b) photograph of subject sitting in MRI.

Sitting Pressures In separate studies, we recorded contact pressures at the IT regions of subjects while they were sitting on each of the cushions A, B, C, and D (Table 1), which were placed on the same plastic chair used in the MRI setting. We measured contact pressures at a rate of 1 Hz, using a commercial pressure mat that was placed in between the buttocks and the cushion/support. We used a Tactilus pressure mat (Sensor Products Inc; Madison, New Jersey) that contained 256 piezoelectric sensors, each 2.5 2.5 cm2, with a capacity of 141 kg/cm2, accuracy of 10 percent, repeatability of 2 percent, hysteresis of 5 percent, and nonlinearity of 1.5 percent. The creep and hysteresis effects inherent to the sensors were automatically corrected by the Tactilus software. Contact pressures were not acquired during the actual MRI scans because of electromagnetic interferences between the pressure mat and MRI. We acquired peak contact pressures under the IT and average pressures across the buttocks-cushion contact area.

During the sitting pressure studies, subjects were also asked to select the most comfortable cushion and the least comfortable cushion.

MR Data Analysis
Tissue deformations were calculated from the MR scans, separately for the gluteus muscles, the superficial fat tissue (between muscle and skin), and the muscle and fat together as one effective soft-tissue material (Figure 2).Tissue deformations were calculated as follows: for muscle, we first obtained the nondeformed thickness from the non-weight-bearing MRI scan by measuring the distance from the apex of the IT vertically to the muscle-fat boundary, Mn. We obtained the deformed muscle thickness in the same subject from a weight-bearing MRI (for a given support/cushion) by again measuring the distance from the IT to the muscle-fat boundary, Mw. The percentage of muscle deformation was calculated as %M = (Mn Mw)/Mn. Similarly, for superficial fat tissue, we measuredthe distance from the muscle-fat boundary directly under the projection of the IT to the skin, in the non-weight-bearing (Fn) and weight bearing (Fw) MRI scans andcalculated the percentage of fat deformation as %F =(Fn Fw)/Fn. For effective soft-tissue deformation, we measured the distance between the apex of the IT and skin in the non-weight-bearing (Sn = Mn + Fn) and weight-bearing (Sw = Mw + Fw) MRI scans and calculated the percentage of effective soft-tissue deformation as %S = (Sn Sw)/Sn. The anatomical landmarks for calculating these tissue thicknesses and deformations are summarized in Table 2 and shown also in Figure 2. We calculated %M, %F, and %S separately for the left and right body sides and then averaged each outcome measure between the body sides of each subject to increase the statistical power of the statistical tests described next.

fig 2a fig 2b

Figure 2.Magnetic resonance imaging scan example of right buttocks in (a) non-weight-bearing and (b) weight-bearing positions, with muscle (Mn and Mw) and fat (Fn and Fw) tissue thicknesses marked on images. IT = ischial tuberosity.

table 2
Table 2. Anatomical landmarks for calculating tissue thicknesses in non-weight-bearing and weight-bearing sitting postures (see also Figure 2).

Statistical Analysis
We obtained descriptive statistics (mean and standard deviations) for peak contact pressures under the IT, average sitting pressures, %M, %F, and %S in the subject group. We conducted a one-way analysis of variance (ANOVA) for the factor of support type (cushions A, B, C, or D or rigid support) to determine whether peak contact pressures differed across supports. We then conducted a similar ANOVA for the average pressures. Likewise, we conducted separate ANOVA tests for %M, %F, and %S to determine whether each parameter differed across supports. For each ANOVA, a corresponding post hoc Tukey-Kramer multipairwise comparison followed for determining specific differences between variables across supports.A value of p < 0.05 was considered statistically significant.


Peak and average contact pressure data (Figure 3) for each of the cushions are reported in Table 3. The rigid support induced the highest peak contact pressure, which was approximately 2.4 times greater than the mean of peakcontact pressures induced by all cushions (p < 0.01, Table 3). The viscoelastic cushion A, which was the thinnest cushion studied herein (Table 1), induced average contactpressures (across the buttocks-cushion contact area) that were about 1.3 times higher than pressures of other cushions (p < 0.05, Table 3). The Tukey-Kramer comparisonsspecifically indicated that when any type of cushion was used, peak pressures were consistently lower than rigid support pressures (p < 0.01) and that thin cushion A induced significantly higher peak pressures than those of thicker cushion D (Table 3). Subjects ranked viscoelastic cushion A equally as being the most comfortable and the least comfortable cushion.

Figure 3.Example of sitting pressure distributions of same subject (male, aged 34 yr, weight 87 kg, body mass index 26 kg/m2) seated on four studied cushions, (a) viscoelastic A, (b) viscoelastic B, (c) foam C, and (d) foam D, and on (e) rigid support.
fig 3a fig 3b
fig 3c fig 3d
fig 3e fig 3 scale

table 3
Table 3. Contact pressures (mean standard deviation) under ischial tuberositiesfor subjects (N = 10) while sitting on each studied cushions.

Tissue deformations for muscle (%M), fat (%F), and effective soft tissue (%S) are plotted in Figure 4 for the four cushions characterized in Table 1, as well as for the rigid support. We found that the percentage of muscle tissue deformation was more than twofold that of fat tissue, regardless of the support type (Figure 4(a) and (b)). Mean values of muscle tissue deformations ranged between 64 and 72 percent across supports, whereas fat tissue deformations ranged between 23 and 35 percent (Figure 4(a) and (b)). The mean of effective soft-tissue deformations (muscle plus fat) ranged between 50 and 59 percent (Figure 4(c)).

fig 4a
fig 4b
fig 4c
Figure 4.Tissue deformations (%) of (a) muscle, (b) fat, and (c) effective soft tissue (muscle and fat together) for all support surfaces. *p < 0.03.

The mean values of all deformation outcome measures were lower while cushions were used, with respect to the rigid support, but only foam cushion D induced statistically significant lower data (p < 0.03) for effective soft-tissue deformations. Generally, the mean of %M, %F, and %S for the viscoelastic cushions was slightly higher than for the foam cushions, but these differences were not statistically significant. Tukey pairwise comparisons identified a statistically significant difference only for the %S measure and, for this measure, only between the foam cushion D (the relatively stiffest, with tangent elastic modulus of 85 kPa at 80% strain; Table 1) and the rigid support (Figure 4(c)). Overall, the data in Figure 4show that commercial viscoelastic or foam cushions reduce deep-tissue deformations in nondisabled individualsin the order of 10 percent, at best, with respect to tissue deformations induced by the rigid support. Specifically, for the best-performing cushion, foam D, deformations reduced by 8, 12, and 9 percent for %M, %F, and %S, respectively, compared with those of the rigid support (Figure 4). Analysis of individual subject data, where extents of individual differences between %M, %F, and %S for each given cushion and corresponding parameters for the rigid support were studied, confirmed that internal tissue deformations while cushions were used were reduced by up to approximately 10 percent for each individual.


We found that commercial cushions reduced internal tissue deformations, surprisingly, in the order of only10 percent (Figure 4). Specifically, effective soft-tissue deformations (muscle plus fat) were around 50 to 60 percent, in the same order of range when subjects were sitting on either cushions or the rigid support (Figure 4). The most rigid cushion evaluated in this study (foam D, Table 1) induced the greatest (statistically significant) decrease in soft-tissue deformations (Figure 4(c)), consistent with the measured contact pressures, which provided relatively low peak pressure recordings for this particular cushion (Figure 3, Table 3). The MRI-based method clearly demonstrated soft-tissue deformations in all subjects and consistently provided quantitative measuresof %M, %F, and %S.

In this study, we determined localized soft-tissue deformations directly under the IT. Soft tissues such as muscle and fat are nearly incompressible because of high liquid content; so sagging of the IT into the soft tissues during weight-bearing causes lateral expansion of the muscles and fat. This result has been observed in previous MRI studies [1415]. In addition, previous articles indicated that soft-tissue deformations maximize under the IT [1415,21]. From a clinical point of view, DTI typi-cally develops under the IT [5]; therefore, we focused on this anatomical area of interest.

Although a reduction of internal tissue deformations in the order of 10 percent when one sits on a cushion may seem to be negligibly significant clinically, this interpretation might not be true. Gefen et al. determined safe and cell-death-inducing deformations for skeletal muscles by applying compressive deformations to tissue-engineered muscle constructs and by fluorescently staining the permanently damaged cells in these constructs over time [22]. They found that exposure to deformations exceeding 77 percent caused immediate muscle cell death in the constructs (Figure 5). This critical deformation level decreased mildly over the first hour of continuous compression and after, which decreased rapidly, so that following 3 hours of continuous compression, even cellssubjected to deformations of 52 percent died (Figure 5). To demonstrate a theoretical implication of the present findings on muscle cell viability in prolonged sitting with or without a cushion, we used the cell-death tolerance of Gefen et al. [22]. The rationale for analysis is that hierarchical computer modeling previously showed that high deformations at the tissue continuum scale are associated with high cell deformations [23]. Based on this result, we expect that the localized elevated muscle and fat deformations presently observed in this MRI study also substantially distort cells in soft tissues under the IT.

fig 5
Figure 5.Theoretical example of how present findings may show difference in muscle cell viability during prolonged sitting with or without cushion. For this purpose, cell-death tolerance of Gefen and colleagues is employed. *Source: Gefen A, Van Nierop B, Bader DL, Oomens CW. Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury. J Biomech. 2008;41(9):200312. [PMID: 18501912] DOI:10.1016/j.jbiomech.2008.03.039 (a) Referring to data in Figure 4(a), assume that subject is sitting motionless on rigid support, which induces gluteal muscle tissue deformations of 72%. In theory, this will allow that subject to sit 75 min continuously without risking deep tissue injury (DTI). (b) If, however, cushion D is used, muscle tissue deformations reduce to 64% (Figure 4(a)), and at this deformation level, subject can sit continuously for 115 min without risking DTI. Hence, though reducing muscle tissue deformations by only 8% with respect to rigid support, cushion D can add considerable time (40 min [53% more]) of safe sitting.

As an example, we integrated a theoretical implication of the data from this study with the muscle cell death threshold of Gefen et al. [22]. Referring to the data in Figure 4(a), let us assume that a subject is sitting motionless on a rigid support, which induces gluteal muscle tissue deformations of 72 percent. Theoretically, this level of muscle deformation will allow that subject to sit75 minutes continuously without risking a DTI (Figure 5(a)). If however, cushion D is used, muscle tissue deformations reduce to 64 percent (Figure 4(a)), and at this deformation level, a subject can, theoretically, sit continuously for 115 minutes without risking a DTI (Figure 5(b)). Hence, though reducing muscle tissue deformations by only 8 percent with respect to the rigid support, cushion D may provide a considerable additional time40 minutes (53% more)of safe sitting. This effect occurs because of the nature of the tolerance curve of muscle cells to deformation [22]. This curve decreases steeply for deformations around 60 to 70 percent (Figure 5)so that even mild reduction in muscle tissue deformation, in the order of 10 percent, can be meaningful in tissue protection time, which can increase substantially as in this example (Figure 5). This example suggests that wheelchair cushions are useful for protecting deep soft tissues subjected to weight-bearing; however, further human studies are needed, particularly in patient populations at increased risk for DTI, before implications to the clinical situation can be made.

Interestingly, foam cushion D, which was the stiffest of all, was found to be the most effective in reducing internal soft-tissue deformations: muscle, fat, and both together (effective soft-tissue) (Figure 4). Also interesting in this regard, a study aimed at characterizing the perception of comfort from wheelchair users point of view reported that firmer cushions are perceived to be more comfortable [24]. From a biomechanical point of view, a complex interplay is likely between tissue stiffness, cushion stiffness, and the body weight (or trunk weight) [20]. If a cushion is too soft, e.g., cushions A and B in this study, the body sinks into it, and the cushion is so deformed that it creates very little (or a too thin) effective interface between the body and the more rigid underlying foundation. Indeed, we noted that cushions A and B induced %M, %F, and %S values that were close to those obtained for sitting on the rigid support (Figure 4).

This study is the first to report internal tissue deformations quantitatively in the human buttocks during sitting on wheelchair cushions. In these nondisabled volunteers, we found that deformations under the IT are maximal in muscle tissue, where the mean is around70 percent, twice more the amount than in superficial fat tissue (~30%), consistent with our previous studies of deep soft-tissue strains in the buttocks of nondisabled volunteers as well as wheelchair users with paraplegia [1415]. Although injury tolerances of muscle versus fat are not yet well characterized, the present tissue deformationdata support the hypothesis that DTI originates in skeletal muscle under weight-bearing bony prominences [1517].

In this study, we used weight-bearing MRI to evaluate wheelchair cushions. Such a method, to our knowledge, has not yet been used. In the past, cushions were evaluated with the use of two major approaches. The first approach was based on clinical outcome of prevention, minimization of onset, or follow-up on healing of pressureulcers. In these previous studies, patients were assigned into groups, each prescribed with one cushion type, and clinical outcomes between the groups were compared in RCTs or other clinical study design techniques [911,25]. Very few RCTs have focused specifically on wheelchair cushions, and even those were inconclusive for an ultimately superior cushion type [3,9,11]. A second approachis biomechanical studies of contact pressures using different cushions [1012,24]. In light of recent literature pointing out that contact pressures cannot predict internal mechanical conditions in deep tissues [4,13,26], studies based solely on contact pressure measurements should be cautiously considered. We believe that the present weight-bearing MRI method may better isolate the specific effects of a cushion in DTI risk assessments of individuals; however, at this stage of the research, obviously, this is a hypothesis only, which should be scientifically proven in future clinical studies.

In the present study, we compared the effects of different cushions on internal soft-tissue deformations in the same subjects. The advantage of the MRI was that it clearly demonstrated the anatomy of the internal soft-tissue deformations in each individual during weight-bearing. This feature is particularly important because, in animal studies, internal tissue deformations were shown to be associated directly with DTI [16]. Unlike RCT, MRI can measure quantitatively the fitting of a cushion to the individual. Although the present study was conducted with nondisabled participating subjects, the %M, %F, and %Soutcome measures can, in the future, directly reflect individual pathoanatomical changes, e.g., those related to disuse muscle atrophy and obesity as seen in patients with spinal cord injury [15,27].

The method used in this study has several potential limitations, which are mostly MRI-related: weight-bearingMR systems are not currently popular; thus their availability is low. Also, MRI may be expensive for use in clinical practice of fitting a cushion to the individual, although if one is considering long-term outcomes, MRI may be cost-effective. In addition, some patients have contraindications for MRI. However, the MRI approach can be extremely useful for the industry in the design phase of cushions, or to some extent in clinical trials, to supplement contact pressure measurements that are currently the gold standard in industry. In the purely clinical context, ultrasound-based systems that are able to demonstrate the anatomy of soft tissues as well as bones can be used for evaluating the same outcome measures obtained presently by the MRI. One recent pilot study already established that using ultrasound to demonstrate soft-tissue thicknesses under the IT in a weight-bearing posture is possible [21], although it might not work with echo-poor cushion materials (e.g., air-filled cushions).

The present study has several additional limitations that are specific to the design. The chair that was used for the MR studies is not identical to a wheelchair. Although the chair was designed and built to simulate overall wheelchair sitting (e.g., in dimensions, as well as in providing armrests and footrests), some effects, like the hammock effect of the wheelchair support [28], were not reproduced in the study design. Also, the chair used in our study is built from plastic, unlike the leather wheelchair seat. These two seats have different properties that may alter the results. Therefore, our data for a rigid support (Figure 4) should not be interpreted as wheelchair without cushion, because a wheelchair seat, even without a cushion, is not completely stiff.


This study established a new MRI-based method for measuring the effects of cushions on internal tissue deformations during weight-bearing. We showed that the method is applicable, but it should now be extended to larger groups, including patient groups susceptible to DTI and should also be correlated with clinical outcomes of DTI prevention and healing. Pending these future studies, weight-bearing MRI could systematically support wheelchair cushion design and selection.


Author Contributions:
The first two authors contributed equally to this study.
Study concept and design: N. Shabshin, A. Gefen.
Acquisition of data: G. Zoizner, V. Ougortsin.
Analysis and interpretation of data: N. Shabshin, G. Zoizner, A. Herman, V. Ougortsin, A. Gefen.
Drafting of manuscript: G. Zoizner, N. Shabshin, A. Gefen.
Critical revision of manuscript for important intellectual content: N. Shabshin, A. Gefen.
Statistical analysis: A. Herman, G. Zoizner.
Study supervision: N. Shabshin, A. Gefen.

Financial Disclosures: The authors have declared that no competing interests exist.
Funding/Support: This material was unfunded at the time of manuscript preparation.
Additional Contributions: Gil Zoizner performed this study in partial fulfillment of the Medical Doctor thesis requirements of the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Additional Information: The Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel, is affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
Institutional Review: The Helsinki committee of Sheba Medical Center, Ramat-Gan, Israel, approved the study (approval 4045/2006), and we conducted the study in 2009. Ten nondisabled volunteers were recruited and provided informed consent.
Participant Follow-Up: The authors do not plan to inform participants of the publication of this study.


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Submitted for publication August 5, 2009. Accepted in revised form November 10, 2009.

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